Novel Sensor Design for Preterm Infants based on Near Infrared Optical Tomography

Project type: Semester project / MSc thesis up to two students in a team

Task: The student will learn the principles of TR NIROT and design a sensor probe, which fits a variety of human heads, and register the system to a human brain atlas.

Keywords: TR NIROT, brain oxygenation, sensor design

Date: Earliest start: November 2018; Latest end:  August 2019

DiCostanza_Novel Sensor Design for Preterm Infants based on Near Infrared Optical Tomography.jpg

Infants born prematurely are at risk for cerebral palsy, cognitive, motor ability, hearing and sight problems. To prevent infants from suffering developmental problems, early imaging of the brain oxygenation is probably very important for intensive care, but unfortunately not yet available. Therefore, our group at BORL is developing a novel time-resolved near infrared optical tomography (TR NIROT) system called Pioneer for monitoring the brain oxygenation of neonates. It is a non-invasive modality designed for bedside usage. The system shines pulsed near infrared light into the tissue and captures the time-of-flight of the photons re-emerging from the tissue with a time-resolved camera with 50 ps resolution. Reconstruction algorithms are applied to obtain 3D images.

The current probe, which is placed on the tissue, is not optimized for human anatomical shapes.  A new probe suitable for clinical tests is needed.

Goal: design a smart sensor probe for Pioneer and the software implementation, to include the novel probe in the imaging software (coregistration).

Topics:  Engineering (mechanical engineering or electrical engineering), medical and health sciences

Aldo Di Costanzo Mata, E-Mail:, Tel: 043 253 30 50
Jingjing Jiang, E-Mail:, Tel: 043 253 30 31
Alexander Kalyanov, E-Mail:, Tel.: 043 253 30 31


Prof. Martin Wolf, E-Mail:, Tel: 044 255 53 46
Biomedical Optics Research Laboratory, Neonatologie, UniversitätsSpital Zürich, 8091 Zürich

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